'Breakthrough' COVID More Likely in People With Problem Drug, Alcohol Use

Discussion in 'Politics' started by wrbtrader, Oct 8, 2021.

  1. wrbtrader

    wrbtrader

    'Breakthrough' COVID More Likely in People With Problem Drug, Alcohol Use

    Oct. 6, 2021, at 8:03 a.m.

    By Robert Preidt, HealthDay Reporter

    [​IMG]

    "First and foremost, vaccination is highly effective for people with substance use disorders, and the overall risk of COVID-19 among vaccinated people with substance use disorders is very low," study co-author Dr. Nora Volkow, director of the U.S. National Institute on Drug Abuse, said in an institute news release.

    She said it's important to encourage folks with drug and alcohol problems to get vaccinated and to acknowledge that even after they do, they have a higher risk of SARS-CoV-2 infection and must take steps to protect themselves.

    For the study, the researchers analyzed electronic health records of nearly 580,000 people in the United States who were fully vaccinated against COVID-19 between Dec. 1, 2020 and Aug. 14, 2021, and who had not previously had COVID.

    Seven percent of those with drug or alcohol problems had breakthrough infections, compared with 3.6% of those without substance use problems.

    Infection rates ranged from 6.8% for tobacco users to 7.8% for those with cannabis use disorder.

    Among people with substance use disorders who had a breakthrough infection, 22.5% were hospitalized, and 1.7% died, the study found. The rates were 1.6% and 0.5%, respectively, among people with drug and alcohol problems but no breakthrough infection.
    • The researchers also found that the risk of severe outcomes after a breakthrough infection was higher in patients with substance use disorders than in others.
    The increased risk of breakthrough infections in people with substance use disorders appears to owe largely to coexisting health conditions and poor health linked to poverty, according to findings published Oct. 6 in the journal World Psychiatry.

    "From previous studies, we knew that people with substance use disorders may be particularly vulnerable to COVID-19 and severe related outcomes," said study co-author Rong Xu, director of the Center for Artificial Intelligence in Drug Discovery at Case Western Reserve University in Cleveland.

    "These results emphasize that, while the vaccine is essential and effective, some of these same risk factors still apply to breakthrough infections," Xu said in the release.

    More information

    The U.S. Centers for Disease Control and Prevention has more on breakthrough infections.

    SOURCE: U.S. National Institute on Drug Abuse, news release, Oct. 6, 2021

    (HealthDay)
    Cannabis abusers at 55% higher risk

    Of SUD patients, the risk of breakthrough COVID-19 infection ranged from 6.8% for patients with tobacco use disorder to 7.8% for those with cannabis use disorder, both significantly higher than 3.6% in the non-SUD group.

    The risk remained higher after controlling for age, sex, ethnicity, and vaccine types for all SUD subtypes except tobacco use disorder and was highest for those who abused cocaine and cannabis (hazard ratio [HR], 2.06 for cocaine, 1.39 for cannabis). This was despite the relative youth and greater chronic disease burden of the latter group, which the study authors said could be due to the effects of cannabis on lung and immune function.

    When the researchers matched patients with and without SUD for chronic conditions and adverse socioeconomic determinants of health (eg, low educational level, unemployment or underemployment), the risk of breakthrough infection was not different, except for those with cannabis use disorder, who were still at 55% higher risk (HR, 1.55).

    All subgroups of patients who received the Pfizer vaccine were at higher risk for breakthrough infection than those given Moderna (HR, 1.49 for those with SUD vs 1.45 for non-SUD patients).

    Breakthrough infections greatly increased the risk of poor outcomes...
    ----------

    The key aspect, if you're fully vaccinated and you're also recently abusing alcohol or abusing drugs...you've increased your risks of having a severe Covid infection if / when you have a breakthrough infection...

    Seems to be similar to the risk factors for those Not Vaccinated and then having a first time Covid infection. I would not be surprised if the same risk factors exist in reinfections.

    P.S. There was a recent story of a famous celebrity that was fully vaccinated that became infected with Covid...he died.

    Not mentioned in the story was that he was an alcoholic.

    wrbtrader
     
    Last edited: Oct 8, 2021
  2. Thank goodness I do not drink or use drugs. I am too smart for that!
     
  3. Alcoholics and drug addicts have far worse things to worry about than Covid. Is there any label you guys won't assign to frighten or shame people into compliance? Your desperation to get full obedience is what has people suspicious. That and the entire democratic party telling everyone don't trust the vaccine prior to 1/20/21 when the vaccine magically became okay to use.
     
  4. Cuddles

    Cuddles

    checkmate dems
     
  5. wrbtrader

    wrbtrader

    I think you should walk away for a while and determine what's really going on for you when every scientific study you view as Democratic politics during a heated U.S. Presidential election year (2020) when both sides (Republicans/Democrats) used the Pandemic to gain votes. :D :rolleyes: :vomit:

    With that said, there's no political discussion by the authors in the scientific study presented in this thread. Simply, the election is over...move on and do your part to help end the Pandemic now that the Covid numbers are declining in the United States.

    Hopefully, if enough people start doing their part to end this Pandemic...the Covid numbers will become low and stabilize there...long enough for the overstepping government to remove their mandates.

    Your meditation for today:



    wrbtrader
     
    Last edited: Oct 9, 2021
  6. The question remains, were they lying then, or are they lying now? The painfully obvious answer...yes and yes. No rational person should trust the government, ever.
     
    FortuneTeller likes this.
  7. wrbtrader

    wrbtrader

    You have not asked any specific questions about the article. Further, the authors are talking about a scientific study where you're stuck in some kind'uv political loop whenever you see the words Covid, Pandemic, or Vaccines. Thus, the reality is that I don't know what your Yes and Yes is about considering the authors are not having a conversation with anyone in this thread.
    • The U.S. election is over...get over it.
    Covid is real, Pandemic is real, Vaccines are real, and Variants of Concern (e.g. Delta Variant) are real.

    Just as important and just as real...most of those hospitalized, ICU admission and dead are those Not Vaccinated. Yet, I'm trying to explore this from fully vaccinated to lead into something that I believe is rarely discussed...

    There may be a socioeconomic reason for such a disparity in the hospitalization of those Not Vaccinated versus those Fully Vaccinated.

    wrbtrader
     
    Last edited: Oct 10, 2021
    El OchoCinco likes this.
  8. wrbtrader

    wrbtrader

    SUDs increase risk for breakthrough COVID-19 infections

    Alison Knopf,
    First published: 08 October 2021
    https://doi.org/10.1002/adaw.33222

    Breakthrough COVID-19 infections — those that occur even if fully vaccinated — are higher for patients with substance use disorders (SUDs) than people without. While the risk even for patients with SUDs for breakthrough infections was low overall, a study published by researchers at the National Institute on Drug Abuse (NIDA) and Case Western Reserve University last week found that it was relatively higher compared to people without SUDs, mainly when considering marijuana.

    Using electronic health records of almost 580,000 fully vaccinated people in the United States, the researchers found that the actual risk for breakthrough infections was highest for people with co-occurring health conditions and adverse socioeconomic determinants of health (lack of adequate housing, for example).

    These co-occurring problems are more common in people with SUDs and are primarily responsible for increasing the risk of breakthrough infections, except for cannabis, which, when other factors were controlled for, still added to the risk...

    ----------

    Now consider the above involving fully vaccinated people in the context that most people in North America that are hospitalized, ICU admission or death have been those Not Vaccinated.
    • If alcohol and drug use (abuse) can increase the risk for fully vaccinated to have a breakthrough Covid infection...it should do the same for those Not Vaccinated ???
    It's logical to assume that alcohol or drug use has a greater impact on the typical Covid patient considering those Not Vaccinated are hospitalized in much greater numbers than those fully vaccinated with a breakthrough Covid infection.

    It has also captured my curiosity about the socioeconomic disparities involving the Not Vaccinated being hospitalized with a severe Covid infection.

    wrbtrader
     
    Last edited: Oct 10, 2021
  9. Bugenhagen

    Bugenhagen

    Which perfect part of the world would you go to? Or do you just have the mind of a teenager as an elderly man.

    The world is not fair, teenagers grow out of this unless they stay in arrested development for life.

    You were a corporal not a captain in real life. Your choices are follow or get out of the way, you have never lead anybody.
     
  10. Wrong, and I stopped blind obedience to so called leaders decades ago. They are to be questioned, always.
     
    #10     Oct 10, 2021