stem cell–based medical microrobot system for knee cartilage regeneration

Discussion in 'Science and Technology' started by easymon1, Jan 28, 2020.

  1. easymon1

    easymon1

    Abstract
    Targeted cell delivery by a magnetically actuated microrobot with a porous structure is a promising technique to enhance the low targeting efficiency of mesenchymal stem cell (MSC) in tissue regeneration. However, the relevant research performed to date is only in its proof-of-concept stage. To use the microrobot in a clinical stage, biocompatibility and biodegradation materials should be considered in the microrobot, and its efficacy needs to be verified using an in vivo model. In this study, we propose a human adipose–derived MSC–based medical microrobot system for knee cartilage regeneration and present an in vivo trial to verify the efficacy of the microrobot using the cartilage defect model. The microrobot system consists of a microrobot body capable of supporting MSCs, an electromagnetic actuation system for three-dimensional targeting of the microrobot, and a magnet for fixation of the microrobot to the damaged cartilage. Each component was designed and fabricated considering the accessibility of the patient and medical staff, as well as clinical safety. The efficacy of the microrobot system was then assessed in the cartilage defect model of rabbit knee with the aim to obtain clinical trial approval.
    https://robotics.sciencemag.org/content/5/38/eaay6626
     
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  2. easymon1

    easymon1

    dartmus likes this.
  3. easymon1

    easymon1

  4. easymon1

    easymon1

    Platelet Rich Plasma







    In recent years, doctors have learned that the body has the ability to heal itself. Platelet-rich plasma therapy is a form of regnerative medicine that can harness those abilities and amplify the natural growth factors your body uses to heal tissue.
    https://www.medicalnewstoday.com/articles/320107.php#how-does-it-work

    Platelet-rich plasma therapy has made headlines, often because it is favored by elite athletes to help them recover from injury.
    https://www.hss.edu/condition-list_prp-injections.asp
     
    Last edited: Jan 28, 2020